This article provides a consolidated overview of the relevant regulatory notices, supplemented by recent developments in regulatory enforcement activities-such as unannounced inspections and sampling inspections-conducted by the National Medical Products Administration (NMPA) and selected provincial and municipal authorities. The aim is to assist enterprises in staying informed of evolving regulatory trends and to reinforce awareness of quality management and compliance requirements.

On July 31, 2025, in order to further regulate and guide the research and evaluation of sunscreen cosmetics, the Cosmetic Supervision Department under China's National Medical Products Administration (NMPA) organized the National Institutes for Food and Drug Control (NIFDC) to draft two technical guidelines: the Technical Guidelines for the Research of Sunscreen Cosmetics (Trial) (Draft for Comments) and the Technical Guidelines for the Research on Quality Control Standards of Sunscreen Cosmetics (Trial) (Draft for Comments), along with their respective drafting instructions. These documents have been released to the public for consultation.

In-vitro Evaluation

Since the concept of New Approach Methodologies (NAMs) was introduced, various methods including in vitro approaches, Threshold of Toxicological Concern (TTC), and computational models have gained favor among toxicological assessment experts. With the increasing capabilities of computational models, key toxicological endpoints such as acute toxicity, skin/eye irritation, sensitization, chronic toxicity, genotoxicity, carcinogenicity, reproductive and developmental toxicity, and toxicokinetics can now be predicted using QSAR models.

On July 31, 2025, the National Institutes for Food and Drug Control (NIFDC) released six Technical Guidelines, including the Technical Guidelines for the Study of Hair Dye Cosmetics (Trial) (Draft for Comments), to solicit public opinions. The following is a detailed interpretation of the Technical Guidelines for the Study of Hair Dye Cosmetics (Trial) (Draft for Comments) and the Technical Guidelines for the Study of Quality Control Standards for Hair Dye Cosmetics (Trial). This aims to assist enterprises in keeping up with regulatory and policy changes in a timely manner, ensuring smooth adaptation to regulatory developments.