According to the EU MDR Regulation, Appendix I General Safety and Performance Requirements (GSPR) Article 10.4 regarding CMR/EDCs substances: The design and manufacture of medical devices should minimize the risk caused by substances or particles (including swarf, degradation products, and processing residues, etc.) that may be generated by the device. These substances mainly refer to CMR and EDCs substances.

On June 30, 2025, the Scientific Committee on Consumer Safety (SCCS) of the European Union issued scientific opinion(SCCS/1678/25) on Diethylamino Hydroxybenzoyl Hexyl Benzoate (DHHB) (CAS/EC No. 302776-68-7/443-860-6). Previously, on February 17, 2025, the SCCS published the scientific opinion on this substance which was open for comments. The scientific advice released this time is consistent with the assessment conclusions proposed during the comment phase and further confirms the maximum safe level and recommends the target maximal level of DnHexP as an impurity in DHHB.

On July 3, 2025, the Vietnam Ministry of Health issued Circular No. 34/2025/TT-BYT, proposing amendments to the cosmetic management regulations. The public consultation period is open until August 18, 2025.

On July 3, 2025, the China National Center for Food Safety Risk Assessment (CFSA) issued a significant announcement, officially soliciting public comments on the draft revision of the National Food Safety Standard - Standard for Uses of Additives in Food Contact Materials and Articles (Industry Draft for Comments). Commissioned by the National Health Commission (NHC), this revision aims to further enhance the safety of food contact materials.