Persistent Organic Pollutants (POPs) are chemical substances that are harmful to humans and exist in or accumulate within the bodies of animals and plants, and circulate in the natural environment over extended periods. POPs are naturally occurring or synthetic organic pollutants characterized by persistence, bioaccumulation, semi-volatility, and high toxicity. POPs include pesticides, industrial chemicals, and by-products unintentionally generated during industrial processes. These pollutants can travel long distances through various environmental media (air, water, organisms), crossing borders and affecting human health and ecosystems even in areas where POPs were never used or produced, causing significant global harm.

On April 14, 2025, the European Commission adopted the draft amendment to the POPs Regulation published on December 4, 2023. This draft aims to revise the restriction requirements for Perfluorooctane Sulfonate (PFOS). In the future, the European Commission will publish the revised POPs Regulation in the Official Journal of the European Union, officially enacting the new restrictions for PFOS.

On September 27, 2024, the European Commission published the amendments to the POPs Regulation — (EU) 2024/2555 and (EU) 2024/2570 — in its Official Journal. These amendments officially reduce the unintentional trace contaminant (UTC) limit for hexabromocyclododecane (HBCDD) from 100 mg/kg to 75 mg/kg and add methoxychlor (also known as methoxychlor) to the list of banned substances under the EU POPs Regulation. These amendments will take effect on the 20th day following their publication in the Official Journal, which is October 17, 2024. With this, the list of banned substances in Annex I of the EU POPs Regulation officially expands from 29 to 30 items.

Persistent Organic Pollutants Review Committee (POPRC) under the European Chemicals Agency (ECHA) initiated a risk management evaluation and public consultation for chlorpyrifos, scientifically known as O, O-diethyl O-(3,5,6-trichloro-2-pyridyl) phosphorothioate.

Perfluorohexane sulfonic acid (PFHxS) is a highly surface-active perfluorinated compound with chemical properties similar to perfluorooctane sulfonic acid (PFOS). Following the ban on PFOS by the Stockholm Convention in 2009, PFHxS has been widely used as a substitute in various products. However, PFHxS is persistent in the environment, capable of long-range transport, and may cause developmental toxicity, neurotoxicity, hepatotoxicity, and reproductive toxicity. At the 10th Conference of the Parties to the Stockholm Convention (SC COP-10), PFHxS, its salts, and related compounds were listed in Annex A of the Convention for elimination, with no exemptions allowed.

The 19th meeting of the Persistent Organic Pollutants Review Committee (POPRC-19) was held from October 9 to 13, 2023, at the headquarters of the Food and Agriculture Organization of the United Nations in Rome, Italy. During this meeting, scientists unanimously recommended that the following two groups of chemicals be considered hazardous and proposed their inclusion in Annex A of the Stockholm Convention: 1. Chlorinated paraffins with a carbon chain length in the range of C14-17 and a chlorine content equal to or greater than 45% (by weight), commonly known as medium-chain chlorinated paraffins or MCCPs. 2. Long-chain perfluorocarboxylic acids (PFCAs), their salts, and related compounds.

On August 8, 2023, the European Commission issued the revised amendment (EU) 2023/1608 to the European Union Persistent Organic Pollutants (POPs) Regulation (EU) 2019/1021. This amendment officially designates PFHxS and its salts, as well as related substances, to be listed in Annex I of the EU POPs Regulation. The revised regulation will come into effect on the 20th day from the date of publication in the official journal and will be applicable to all member states.

On June 20, 2023, the European Chemicals Agency (ECHA) announced that the European Union Enforcement Forum plans to carry out the 13th Joint Enforcement Project (REF-13) and the 3rd Major Enforcement Project on Biocides (BEF-3) within the EU by 2025.

On May 30, 2023, the European Commission announced its decision to adopt the proposal to amend Annex I of Regulation (EU) 2019/1021. This decision confirms the inclusion of PFHxS and its salts and related compounds in the list of banned substances under the POPs Regulation.

On May 12, 2023, the 11th Conference of the Parties to the Stockholm Convention made a significant decision to eliminate the use of three persistent organic pollutants. These substances include the pesticide Methoxychlor, the industrial chemical Dechlorane Plus, and UV-328, and they have been added to Annex A of the Convention. In the near future, the Parties to the Convention will take action to regulate these three substances, and the European Union will also incorporate them into the EU POPs regulation.